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  • I1404 - Anti-Interleukin-1 Receptor Accessory Protein, C-Terminal antibody produced in rabbit

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I1404 Sigma

Anti-Interleukin-1 Receptor Accessory Protein, C-Terminal antibody produced in rabbit

buffered aqueous solution, affinity isolated antibody

Synonym: Anti-IL-1RAcP

Description

Immunogen

synthetic peptide corresponding to amino acids 549-569 of the C-terminal region of human interleukin-1 receptor accessory protein (IL-1RacP). This sequence differs from that of mouse by three amino acids.

Physical form

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

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Biochem/physiol Actions

Interleukin-1 receptor accessory protein (IL-1RAcP) stabilizes IL-1/IL-1R complex and is essential for signaling mediated by this complex.1 It regulates the immune responses mediated by the IL-1 family cytokines. The isoforms of IL-1RAcP also suppress the synapse formation in cortical neurons, linking the immune system and the synapse formation in the brain.

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