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I1411 Sigma

ITX3

≥98% (HPLC)

Synonym: 2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-thiazolo[3,2-a]benzimidazol-3(2H)-one

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Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

GTP Binding Proteins (Low Molecular Weight)

The approximately 150 members of the human Ras superfamily of low molecular weight GTP binding proteins function as regulators of diverse cellular processes. Most Ras superfamily members have intrins...
Keywords: Absorption, Acetylations, Atomic absorption spectroscopy, Cancer, Cellular processes, Diseases, Enzyme activity, Farnesylations, Geranylgeranylations, Myristoylations, Palmitoylations, Post translational modifications, Rearrangements, Transduction

Peer-Reviewed Papers
15

References

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