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I146 Sigma

IB-MECA

solid, ≥98% (HPLC)

Synonym: 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide, N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide

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Properties

Related Categories Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Cell Biology, Cell Signaling and Neuroscience, Neuroscience,
InChI Key   HUJXGQILHAUCCV-MOROJQBDSA-N
assay   ≥98% (HPLC)
form   solid
color   white
solubility   ethanol: >10 mg/mL (hot)
  DMSO: >5 mg/mL
  H2O: insoluble
  aqueous acid: insoluble
  aqueous base: insoluble
storage temp.   2-8°C
Gene Information   human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Description

Legal Information

Sold under license from the National Institutes of Health.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Application

IB-MECA has been used for intraocular pressure and corneal thickness measurements in rabbits.

Biochem/physiol Actions

Selective A3 adenosine receptor agonist.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Fluorescent G protein-coupled receptors (GPCRs)

G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins and the targets for almost half of the clinical drugs in the market today. Advances in X-ray crystallography and ot...
Mike Earley, Market Segment Manager, Sigma Life Science
Biofiles Vol. 8, No. 4
Keywords: Clinical, Confocal microscopy, Ligands, Microscopy

Peer-Reviewed Papers
15

References

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