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  • I157 - Anti-Inositol 1,4,5-Triphosphate Receptor (Type I) antibody produced in rabbit

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I157 Sigma

Anti-Inositol 1,4,5-Triphosphate Receptor (Type I) antibody produced in rabbit

whole antiserum, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   human, mouse, rat
application(s)   immunohistochemistry (frozen sections): 1:100
  immunoprecipitation: suitable
  western blot: 1:1,000
clone   polyclonal
antibody form   whole antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~240 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ITPR1(3708)
mouse ... Itpr1(16438)
rat ... Itpr1(25262)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide derived from amino acids 1829-1848 of cytoplasmic C-terminal domain of human inositol 1,4,5-triphosphate receptor, type I (IP3R-I). This sequence is 100% conserved in human, mouse and rat IP3R-I.

General description

The gene ITPR1 (inositol 1,4,5-triphosphate receptor type 1) encodes an intracellular receptor that binds to inositol 1,4,5 trisphosphate. It is localized to membranes of endoplasmatic or sarcoplasmatic (in muscle cells) reticulum. The gene is mapped to human chromosome 3p26.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide

Specificity

The antibody reacts specifically with IP3R-I in microsomes prepared from liver epithelial cells, cerebellum, and vascular smooth muscle cells.

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Biochem/physiol Actions

The ligand-gated calcium channel encoded by the gene ITPR1 (inositol 1,4,5-triphosphate receptor type 1) is stimulated upon binding to its ligand inositol 1,4,5-triphosphate, and mediates intracellular calcium signaling. It facilitates the release of Ca2+ from endoplasmic reticulum and modulates intracellular Ca2+ concentration. This is a crucial mechanism in the initial stages of myoblast differentiation. Mutations in this gene have been associated with sporadic infantile-onset cerebellar ataxia.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  nwg
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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