• USA Home
  • I157 - Anti-Inositol 1,4,5-Triphosphate Receptor (Type I) antibody produced in rabbit

I157 Sigma

Anti-Inositol 1,4,5-Triphosphate Receptor (Type I) antibody produced in rabbit

whole antiserum, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   human, mouse, rat
application(s)   immunohistochemistry (frozen sections): 1:100
  immunoprecipitation: suitable
  western blot: 1:1,000
clone   polyclonal
antibody form   whole antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~240 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ITPR1(3708)
mouse ... Itpr1(16438)
rat ... Itpr1(25262)
biological source   rabbit
conjugate   unconjugated



synthetic peptide derived from amino acids 1829-1848 of cytoplasmic C-terminal domain of human inositol 1,4,5-triphosphate receptor, type I (IP3R-I). This sequence is 100% conserved in human, mouse and rat IP3R-I.

General description

The gene ITPR1 (inositol 1,4,5-triphosphate receptor type 1) encodes an intracellular receptor that binds to inositol 1,4,5 trisphosphate. It is localized to membranes of endoplasmatic or sarcoplasmatic (in muscle cells) reticulum. The gene is mapped to human chromosome 3p26.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide


The antibody reacts specifically with IP3R-I in microsomes prepared from liver epithelial cells, cerebellum, and vascular smooth muscle cells.

Features and Benefits

Antibody Bioguarantee
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

The ligand-gated calcium channel encoded by the gene ITPR1 (inositol 1,4,5-triphosphate receptor type 1) is stimulated upon binding to its ligand inositol 1,4,5-triphosphate, and mediates intracellular calcium signaling. It facilitates the release of Ca2+ from endoplasmic reticulum and modulates intracellular Ca2+ concentration. This is a crucial mechanism in the initial stages of myoblast differentiation. Mutations in this gene have been associated with sporadic infantile-onset cerebellar ataxia.

Price and Availability

Antibody Explorer

Explore with Confidence
Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  nwg
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?