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  • I1654 - Anti-IRAK2 (546-564) antibody produced in rabbit

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I1654 Sigma

Anti-IRAK2 (546-564) antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody

Synonym: Anti-Interleukin-1 Receptor-Associated Kinase 2

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Gene Regulation, Antibodies for Gene Regulation and Expression,
species reactivity   human
application(s)   western blot: 0.5-1 μg/mL using HeLa or K562 cell lysates
clone   polyclonal
concentration   ~0.5 mg/mL
antibody form   affinity isolated antibody
mol wt   antigen mol wt 65 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... IRAK2(3656)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 546-564 of human IL-1 receptor-associated kinase 2 (IRAK2).

General description

The gene IRAK2 (interleukin 1 receptor associated kinase 2) encodes a member of the IRAK/Pelle family. It is an important signaling molecule of the TLR (Toll like receptor)/IL1-R (interleukin 1 receptor) superfamily. The members of IRAK family are characterized by the presence of an N-terminal DD (death domain) and a C-terminal Ser/Thr kinase or kinase-like domain. The gene is mapped to human chromosome 3p25.3-3p24.1.

Biochem/physiol Actions

The members of this family activate the transcription factor NF-κB (nuclear factor κ B) via IL-R1 (interleukin receptor type 1) and TLR (Toll-Like Receptor) mediated inflammatory/immune response. The receptor IL-R1 binds to its ligand proinflammatory cytokine IL-1, and this binding facilitates the association of IL-R1 with IL-1 receptor accessory protein (IL-1RAcP). This complex then recruits myeloid differentiation protein (MyD88), an intracellular TIR-containing adaptor. MyD88, then recruits IRAK1, IRAK2, IRAK4 and IRAK-M. These kinases interact with TRAF6 (TNF receptor-associated factor 6), which in turn links to NFκB-inducing kinase (NIK). NIK activates the IκB kinase complex (IKKα and IKKβ), which in turn phosphorylates IκB. This final phosphorylation leads to ubiquitin-proteasome-mediated degradation resulting in the activation of NF-κB.

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