I1911 Sigma


≥98% (HPLC)

Synonym: 1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone

  • CAS Number 314245-33-5

  • Empirical Formula (Hill Notation) C18H21FN2O

  • Molecular Weight 300.37

  •  MDL number MFCD01917473


Related Categories Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I, Intracellular Protein Degradation,
assay   ≥98% (HPLC)
form   powder
color   off-white to light brown
solubility   DMSO: >10 mg/mL
storage temp.   2-8°C


Biochem/physiol Actions

IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome. The proteasome mediates the cellular degradation of oxidized, damaged and misfolded proteins which, if not removed, accumulate and become toxic to cells. Proteins targeted for proteasomal degradation are first ubiquitinated, with longer length ubiquitin chains interacting more strongly with the proteasome. Deubiquitinating enzymes (DUBs) such as USP14 interfere with the degradation process. IU1 inhibits USP14-mediated ubiquitin "chain-trimming" thereby enhancing substrate degradation by the proteasome. The compound may help to eliminate toxic proteins more effectively by enhancing their degradation.

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