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I2143 Sigma

Anti-Interleukin-6 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-IL-6

Description

Immunogen

Purified human recombinant IL-6 produced in E. coli.

General description

Interleukin-6 (IL-6) is a cytokine produced by activated T cells, endothelial cells, fibroblasts and activated monocytes or macrophages. It plays a crucial role in regulating the acute phase response as well as responses occurs after injury and infection. It interacts with IL-2 and facilitates in the proliferation of T lymphocytes. Anti-Interleukin-6 antibody can be used for selective neutralization of human IL-6 bioactivity in cell culture. It can also be used in radioimmunoassay (RIA) (diluted 1:60,000). Rabbit anti-Interleukin-6 antibody reacts specifically with natural and recombinant human IL-6 but not with recombinant human IL-1β, recombinant human TNF-α or recombinant mouse IL-6.

Physical form

Solution, 0.2 μm filtered, in 0.5 mL phosphate buffered saline, pH 7.4.

Specificity

The antibody will neutralize the biological activity of human IL-6 in cell culture. The antibody does not cross-react with human IL-1β, TNF-α or mouse IL-6.

Application

Anti-Interleukin-6 antibody can be used in western blotting and ELISA for studying human IL-6. It can also be used for dot blot immunoassay.

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