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I2535 Sigma

InsR (1011-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: CD220, HHF5, Insulin Receptor (1011-end), active, GST tagged

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   2281-3086 nmol/min·mg
mol wt   mol wt ~70 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... INSR(3643)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

INSR (insulin receptor) belongs to the receptor tyrosine kinase family and is a cell surface receptor. Insulin binding to INSR results in autophosphorylation and increased catalytic activity. These events are important for downstream signalling. Insulin/INSR signaling is crucial in the central nervous system for controlling blood glucose levels, synaptic plasticity, dendritic growth, regulation of electrophysiological activity, astrocytes proliferation and neuronal cell death. Mutations in INSR are associated with hyperinsulinemic hypoglycemia syndrome.

Legal Information

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Price and Availability


All labs need water
Protocols & Articles

Articles

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism ...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 2011
Keywords: Apoptosis, Biological processes, Carboxylations, Catalog, Diabetes, Gene expression, Gluconeogenesis, Glycolysis, Hormones, Metabolism, Metabolites, Transcription, Transduction, Type

Peer-Reviewed Papers
15

References

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