I2644 Sigma

Interleukin-2 human

IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym: IL-2, Interleukin-2, T-cell growth factor, hIL-2



Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Biochem/physiol Actions

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.


10 μg in poly bottle

Physical form

Lyophilized, 0.2 μm filtered, no additives.

Price and Availability

All labs need water
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option:
Where can I find information on the specific activity of Product I2644, Interleukin-2 human - recombinant?
The EC50 has been determined by dose-dependent stimulation of the proliferation of murine CTLL-2 cells.  You can find the lot specific value for the EC50 of this product on the Certificate of Analysis.  Certificates of Analysis can be viewed on our website by entering the lot number on the product detail page (for I2644):
Is Product I2644, Interleukin-2 human - recombinant, endotoxin tested?
Yes, the endotoxin levels are reported on the Certificate of Analysis.  Certificates of Analysis can be viewed on our website by entering the lot number on the product page (for I2644):|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC
How can I convert the EC50 of interleukin from ng/mL to units/mL when using Product I2644, Interleukin-2 human - recombinant?
The specific activity in Units/mg = 1 × 106 / ED50 (in ng/ml).
How should I dissolve Product I2644, Interleukin-2 human - recombinant?
Reconstitute the contents of the vial using 100 mM acetic acid to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers.
How should solutions of Product I2644, Interleukin-2 human - recombinant, be stored?
Interleukin solutions can be stored at 2-8°C for up to 1 week. For extended storage, freeze at -20°C in working aliquots to avoid freezing and thawing.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
  What kind of solution is the A5955 - Antibiotic Antimycotic Solution (100×), Stabilized product suspended in?
A5955 - Antibiotic Antimycotic Solution (100×), Stabilized is supsended in a sodium citrate buffer solution. Source: Israel production group
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Protocols & Articles


Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages...
Jennifer Fries
BioFiles 2009, 4.5, 16.
Keywords: Anti-inflammatory agents, Antitumor agents, Cancer, Cell proliferation, Gene expression, Growth factors, Transcription

Peer-Reviewed Papers


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