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I2660 Sigma

IRAK2, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: MG C150550

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   5-7 nmol/min·mg
mol wt   mol wt ~103 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... IRAK2(3656)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

IRAK2 (interleukin-1 receptor-associated kinase 2) belongs to the IRAK family and is ubiquitously expressed. The protein contains an amino terminal death domain and a central kinase domain. IRAK2 is required for TLR (Toll-like receptor) signaling. Upon activation of TLR4 and TLR8, IRAK2 is crucial for the induction of TNF (tumor necrosis factor). It also regulates endoplasmic reticulum stress signaling.

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