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I2768 Sigma

Monoclonal Anti-IgD antibody produced in mouse

clone HJ9, purified immunoglobulin, buffered aqueous solution

Synonym: Monoclonal Anti-Human IgD

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Properties

Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Cell Biology, Antibodies for Immune Cell Signaling and Blood,
species reactivity   human
application(s)   flow cytometry: 5 μL using 1 × 106 cells
clone   HJ9, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   wet ice
storage temp.   2-8°C
Gene Information   human ... IGHD(3495)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human IgD

General description

The gene IgD (immunoglobulin heavy constant δ) encodes the major antigen receptor isotype that is expressed on the surface of B lymphocytes along with IgM. There are two forms of IgD, the membrane-bound form and the form secreted in to the serum. The serum IgD constitutes only 0.2% of all immunoglobulins. The δ heavy chain of IgD contains a four-domain structure comprising of a variable region (VH), and three constant region domains named Cδ1, Cδ2, Cδ3. The C region also contains an unusual hinge region of approximately 64 residues. The N-terminal end is referred to as GalN-rich segment. The C-terminal end is rich in glutamic acid and lysine and is referred to as high-charge segment.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Specificity

Recognizes the delta chain of human IgD and is not reactive with heavy chains from human IgG1, IgG2, IgG3, IgG4, IgM, IgA, or kappa and lambda light chains.

Other Notes

IgD is expressed on peripheral B cells and is used as a pan-B cell marker.

Features and Benefits

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Biochem/physiol Actions

IgD (immunoglobulin heavy constant δ) is a class of immunoglobulin that may function in facilitating antibody secretion and participating in early antibody secretion. The serum IgD level may vary from undetectable to 140mg/L. Increased levels of serum IgD has been observed in clinical conditions, such as IgD myeloma, Hodgkin′s disease, sarcoidosis and tuberculosis, aspergillosis, ataxia-telangiectasia, AIDS, hyperimmunoglobulinemia D and periodic fever (HIDS) syndrome. IgD induces inflammatory cytokines, such as TNF (tumor necrosis factor)-α, IL-1β (interleukin 1β), IL-6 and may regulate several interactions and processes related to inflammation and immune response. It may also participate in the pathogenesis of HIDS.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

Articles

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Peer-Reviewed Papers
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References

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