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I3265 Sigma

Interferon-γ human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, cell culture tested

Synonym: IFN-γ

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Description

Analysis Note

The biological activity is measured by a viral resistance assay.

Physical form

Lyophilized from phosphate buffered saline.

Application

Interferon-γ human has been used:
• to study the effect of interferon-γ on cultured trophoblasts in absence and presence of fibronectin
• to analyse factors which participate in the production of antibody microarrays on glass support
• for ELISA (enzyme-linked immunosorbent assay) method to understand the effect of interferon-γ in human gingival fibroblasts in presence of bacterial challenge

Biochem/physiol Actions

IFNG (interferon-γ) is a type-2 interferon which is produced by Th (T helper cells)-1 lymphocytes, CD8 cytotoxic lymphocytes, natural killer (NK) cells, and natural killer T (NKT) cells. It plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections. High expression of IFNG is common in many autoimmune diseases, such as systemic lupus erythematosis, Sjögren syndrome, inflammatory bowel disease and multiple sclerosis.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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