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I3394 Sigma

Interleukin-9 human

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, cell culture tested

Synonym: IL-9

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
recombinant   expressed in baculovirus infected Sf21 cells
assay   ≥97% (SDS-PAGE and N-terminal analysis)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... IL9(3578)

Description

Analysis Note

The proliferative activity of recombinant human IL-9 is tested in culture using M07e cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Biochem/physiol Actions

Interleukin-9 was first identified as a T cell derived growth factor. High affinity receptors for IL-9 are located on a variety of hematopoietic cells including T cells and macrophages. There is high sequence homology between mouse and human IL-9. Overall sequence homology between human and mouse IL-9 cDNAs is 56% and 67% identity at the amino acid and nucleotide levels, respectively. MO7e cells are responsive to both mouse and human IL-9, while only mouse IL-9 can stimulate mouse P40-responsive cell lines. Mouse IL-9 enhances erythroid burst formation by normal mouse bone marrow cells. In addition, mouse IL-9 induces day 15 fetal thymocyte proliferation in the presence of IL-2 and enhances the mast cell growth elicited by IL-3 or IL-4. Mouse IL-9 also supports the growth of certain helper T cell clones. Human IL-9 supports erythroid colony formation and synergizes with IL-4 in the production of IgE and IgG.

Interleukin-9 was first identified as a T cell derived growth factor. High affinity receptors for IL-9 are located on a variety of hematopoietic cells including T cells and macrophages.

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Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages...
Jennifer Fries
BioFiles 2009, 4.5, 16.
Keywords: Anti-inflammatory agents, Antitumor agents, Cancer, Cell proliferation, Gene expression, Growth factors, Transcription

Peer-Reviewed Papers
15

References

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