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I3525 Sigma

Interleukin-17A human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: CTLA-8, IL-17



Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
recombinant   expressed in E. coli
assay   ≥98% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... IL17A(3605)


Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Analysis Note

• The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
• Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

Physical form

Lyophilized with no additives.

Biochem/physiol Actions

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Price and Availability

All labs need water
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
What is the solution from which product I3525, Interleukin-17A human recombinant, was prepared?
Product I3525, Recombinant Human IL-17A, was lyophilized with no additives, which means it was lyophilized from water and may contain trace amounts of 0.1% TFA (pH 2.0) from being HPLC-purified.
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Protocols & Articles
Peer-Reviewed Papers


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