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I3529 Sigma

Introduction to Protein Architecture

  •  ISBN-10 0-19-850474-8

  •  ISBN-13 978-0-19-850474-0

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publication info   A.M. Lesk, Oxford University Press, UK, 2001, 304 pp., soft cover
mfr. no.   Oxford University Press

Description

General description

The structures and functions of proteins unlock the secrets inherent in genomes. The emphasis is on proteins as three-dimensional patterns. It explains the general characteristics of proteins that underlie the great variety of folding patterns observed in nature. Topics treated include: Pattern and form in protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why).

Table of Contents

Chapter 1: The photosynthetic reaction center: protein structure in a microcosm
The reaction center from Rhodopseudomonas viridis
Conclusions
Chapter 2: In vivo, in vitro, in silicio
Why study proteins?
Protein structure and conformation
The known protein structures
The Protein Data Bank
The World Wide Web
Summary
Glossary
Chapter 3: Pattern and form in protein structure
Helices and sheets
The hierarchical nature of protein architecture
An album of small structures
Classification of protein structures
Loops
Protein-ligand interactions
Chapter 4: The varieties of protein structure
Catalogues of protein structure
The known structures
a-helical proteins
B-sheet proteins
a + B proteins
a / B proteins
Closed B-a-B barrel structures
Irregular structures
Conclusions
Chapter 5: Molecular evolution
Evolution of DNA and proteins
Evolution of protein structures
Structural relationships among related molecules
Chapter 6: Evolution in selected protein families
Evolution of the globins
Evolution of serine proteinases of the chymotrypsin family
NAD-binding domains of dehydrogenases
Chapter 7: Some proteins of the immune system
Antibody structure
Proteins of the Major Histocompatibility Complex
T-cell receptors
Chapter 8: Conformational changes in proteins
Structural changes arising from change in state of ligation
Hinge motions in proteins
The ′helix interface shear′ mechanism of conformational change
The allosteric change in haemoglobin
Serpins: SERine Proteinase INhibitors
Higher-level structural changes
Appendix 1: An album for browsing
Appendix 2: Useful web sites

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