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I3653 Sigma

Anti-Interferon β antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IFN-β

Description

Immunogen

recombinant human IFN-β, expressed in Escherichia coli.

General description

Type I interferons are proteins produced in response to inducers like viral infection and can be divided into α and β subtypes. IFN-β provokes high antiproliferation response in certain cells like embryonal carcinoma, melanoma and melanocytes. It also has high potency in treatment of multiple sclerosis and certain cancers. Anti-interferon β antibody can be used in western blot. Goat anti-interferon β antibody reacts specifically with human interferon-β and has shown no cross reactivity with recombinant human interferon-γ.

Physical form

Lyophilized from a solution in phosphate buffered saline containing carbohydrates.

Specificity

The antibody will neutralize the biological activity of recombinant human IFN-β. It will not block the biological activity of recombinant human IFN-α or IFN-γ.

Application

Anti-interferon β antibody can be used in immunoblotting. It can also be used to neutralize the bioactivity of recombinant human interferon-β.

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