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  • I4028 - Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

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I4028 Sigma

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

Synonym: Anti-IL-18 Receptor

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   human
application(s)   indirect ELISA: 0.5-1.0 μg/mL
  western blot: 1-2 μg/mL
clone   70625.111, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG1
storage temp.   −20°C
Gene Information   human ... IL18R1(8809)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

General description

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Biochem/physiol Actions

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

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