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I4029 Sigma

Ion Channels and Disease

  •  ISBN-10 0-12-065310-9

  •  ISBN-13 978-0-12-065310-2

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Related Categories Books and Software, Cell Signaling Books, Ion Channel Books, Labware
publication info   F.M. Ashcroft, Academic Press, 2000, 481 pp., hard cover
mfr. no.   Elsevier

Description

General description

A number of human and animal diseases have been found to result from mutations in the genes encoding ion channel proteins, and are referred to as channelopathies. This chronicles our understanding of the molecular basis of ion channel diseases. It includes the relevant aspects of molecular biology and biophysics and a description of methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.

Table of Contents

Ch. 1. Introduction
Ch. 2. From Gene to Protein
Ch. 3. How Channels Work
Ch. 4. Studying Ion Channels
Ch. 5. Voltage-Gated Na"superscript +" Channels
Ch. 6. Voltage-Gated K"superscript +" Channels
Ch. 7. Ca-Activated K"superscript +" Channels
Ch. 8. Inwardly Rectifying K"superscript +" Channels
Ch. 9. Voltage-Gated Ca"superscript 2+" Channels
Ch. 10. Voltage-Gated Cl"superscript -" Channels
Ch. 11. Cyclic Nucleotide-Gated Channels
Ch. 12. Cystic Fibrosis Transmembrane Conductance Regulator
Ch. 13. Epithelial Na"superscript +" Channels
Ch. 14. Ligand-Gated Ca"superscript 2+" Channels
Ch. 15. Acetylcholine Receptors
Ch. 16. Glutamate Receptors
Ch. 17. Glycine Receptors
Ch. 18. Gaba"subscript A" Receptors
Ch. 19. Water Channels
Ch. 20. Gap Junction Channels
Ch. 21. Antibodies to Ion Channels
Ch. 22. Ion Channels in Viruses
Ch. 23. Ion Channels as Lethal Agents
Ch. 24. A Ragbag of Channels
A Last Word
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