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  • I4153 - Anti-Interleukin-12 Receptor β1 antibody produced in goat

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I4153 Sigma

Anti-Interleukin-12 Receptor β1 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IL-12 Receptor β1

Description

Immunogen

recombinant human IL-12 Rβ1 extracellular domain, expressed in NSO cells

General description

IL-12 also known as Natural Killer Cell Stimulatory Factor (NKSF) is a 75kD protein that belongs to type I cytokine receptor family and is produced mainly by monocytes and NK cells. IL-12 signals with the help of IL-12 receptor made up of two subunits designated β1 and β2. Interleukin-12 receptor subunit β-1 binds interleukin-12 with low affinity and facilitates in IL12 transduction. Anti-interleukin-12 receptor β1 antibody can be used in ELISA (0.5-1.0 μg/mL) using recombinant human IL-12 Rβ1. Goat anti-interleukin-12 receptor β1 antibody has shown 5% (approx.) cross-reactivity with recombinant mouse IL-12 Rβ1.

Physical form

Lyophilized from 0.2 μm filtered solution of phosphate buffered saline

Specificity

The antibody shows 5% cross-reactivity with recombinant mouse IL-12 Rβ1.

Application

Anti-interleukin-12 receptor β1 antibody can be used in immunoblotting for localization and detection of recombinant human IL-12 Rβ1.

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