I4276 Sigma

Interferon-αA human

≥95%, cell culture tested, buffered aqueous solution, recombinant, expressed in E. coli

Synonym: IFN-αA, Interferon-α2A



Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.

Physical form

Supplied as a solution in 5 mM sodium acetate, pH 4.0.


Interferon-αA human has been used to:
• study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
• study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
• compare the effect of Monascus pigment derivatives on hepatitis C virus replication

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.

Price and Availability

All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Renal Cell Cancer

Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport waste molecules from the blo...
Keywords: Cancer, Clinical, Gene expression, Growth factors, Ligands, Oncology, Urology

Peer-Reviewed Papers


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