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  • I4278 - Anti-Interleukin-18 Receptor antibody produced in goat

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I4278 Sigma

Anti-Interleukin-18 Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IL-18 Receptor

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   human
application(s)   indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... IL18R1(8809)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

General description

Interleukin 18 also refers as interferon-γ inducing factor (IGIF) is a proinflammatory cytokine produced on cell injury or trauma. It has a pivotal role in T cell helper type 1 (Th1) response to stimulate IFN-γ production in T cells and NK cells. Interleukin-18 Receptor (IL-18R) is a 60-110kD protein, expressed mainly in normal peripheral blood lymphocytes. IL-18R also expresses on T and B cell lineages and can activate NF-κB by recruiting IL-1 R-activating kinase (IRAK) and TNFR associated factor-6 (TRAF-6) which in turn activates NF-κB-inducing kinase (NIK). Anti-Interleukin-18 Receptor antibody can be used for neutralizing the biological activity of recombinant human IL-18 R. Goat anti-Interleukin-18 Receptor antibody reacts specifically with recombinant human IL-18 R. The product exhibits 5% cross-reactivity with recombinant mouse IL-18 R.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Specificity

The antibody will neutralize the biological activity of human IL-18 receptor.

Application

Anti-Interleukin-18 Receptor antibody may be used for immunoblotting at a working antibody concentration of 0.1-0.2 μg/ml using human IL-18 R. It can also be used in indirect ELISA (working concentration:-0.5-1.0 μg/ml).

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