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I4402 Sigma

Insulin-like Growth Factor Binding Protein-4 human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: IGFBP-4

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, IGF Binding Proteins,
recombinant   expressed in NSO cells
assay   >97% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt 25 kDa by SDS-PAGE (non-reducing)
  mol wt 32 kDa by SDS-PAGE (reducing)
purified by   affinity chromatography (IGF-I ligand)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   human ... IGFBP4(3487)

Description

Analysis Note

The biological activity is measured by its ability to inhibit activity of recombinant human IGF-1 or recombinant human IGF-II on MCF-7 cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 50 μg bovine serum albumin per 1 μg of cytokine.

Biochem/physiol Actions

IGFBPs (insulin like growth factor binding proteins) regulate bioavailability of IGFs (insulin like growth factors) in cells. Binding between IGFs and IGFBPs reduces the availability of the IGFs. However, IGFBPs also concentrate IGFs in specific areas to potentiate their effects at right time. IGFBP4 binds to IGF-1.

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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