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I4770 Sigma

Anti-Interleukin-9 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-IL-9

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   human
application(s)   neutralization: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... IL9(3578)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human IL-9 expressed in Sf 21 insect cells.

General description

Interleukin-9 (IL-9) is a pleotropic cytokine produced by activated T cells and also by mast cells in response to LPS and IL-1. The production of IL-9 is amplified by TGF-β, IL-2 and IL-25. The biological effects of IL-9 are mediated by IL-9 receptor (IL-9R) that is made up of an α and a γ chain. IL-9 signalling results in the activation of major signalling pathways involving STAT1, -3 and -5, MAPK, PI3K and IRS. IL-9 is a pro-inflammatory cytokine and promotes allergic inflammation and airway remodelling in lungs. It also is important in cell growth and differentiation of T cells, B cells, mast cells, hematopoietic progenitors, epithelial cells and airway smooth muscle cells
Monoclonal Anti-Human Interleukin-9 recognizes human IL-9. It does not neutralize the activity of recombinant mouse IL-9. In ELISA and immunoblotting, it shows 20% cross reactivity with mouse IL-9.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Specificity

The antibody neutralizes the biological activity of recombinant human IL-9, but not recombinant mouse IL-9.

Preparation Note

Purified using protein G.

Application

Anti-Interleukin-9 antibody may be used for immunoblotting at a working concentration of 1.0 μg/ml. For ELISA a concentration of 0.5 μg/ml is recommended. The antibody is also suitable for neutralization reactions.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

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