Ibuprofen

Papers

Revealing Equilibrium And Rate Constants Of Weak And Fast Noncovalent Interactions. Mironov, G.G., et al. Anal. Chem. 83, 2364-70, (2011)

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Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Loretta Aureli et al J. Med. Chem. 48, 2469-79, (2005)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies. Carlos Velázquez et al J. Med. Chem. 48, 4061-7, (2005)

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Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents. C Selvam et al Bioorg. Med. Chem. Lett. 15, 1793-7, (2005)

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Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents. Stanislav Gobec et al Bioorg. Med. Chem. Lett. 15, 5170-5, (2005)

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UDP-glucuronosyltransferases and clinical drug-drug interactions. Tony K L Kiang et al Pharmacol. Ther. 106, 97-132, (2005)

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Expanding the ChemGPS chemical space with natural products. Josefin Larsson et al J. Nat. Prod. 68, 985-91, (2005)

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The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Nicholas Stock et al Bioorg. Med. Chem. Lett. 16, 2219-23, (2006)

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Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors. Hiroko Sano et al Bioorg. Med. Chem. Lett. 16, 3068-72, (2006)

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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Gregory Kaler et al J. Biol. Chem. 282, 23841-53, (2007)

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Human serum albumin binding assay based on displacement of a non selective fluorescent inhibitor. Atli Thorarensen et al Bioorg. Med. Chem. Lett. 17, 4646-9, (2007)

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One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities. Sham M Sondhi et al Bioorg. Med. Chem. 15, 3334-44, (2007)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies. Carlos A Velázquez et al Bioorg. Med. Chem. 15, 4767-74, (2007)

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Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. Y Harrak et al Bioorg. Med. Chem. 15, 4876-90, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties. Ioanna C Siskou et al Bioorg. Med. Chem. 15, 951-61, (2007)

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Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents. Khurshid I Molvi et al Eur. J. Med. Chem. 42, 1049-58, (2007)

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Non-carboxylic analogues of arylpropionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential. Kamel A Metwally et al Eur. J. Med. Chem. 42, 152-60, (2007)

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Aspirin antagonism in isoniazid treatment of tuberculosis in mice. Sean T Byrne et al Antimicrob. Agents Chemother. 51, 794-5, (2007)

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New phenylpropenoids, bis(1-phenylethyl)phenols, bisquinolinone alkaloid, and anti-inflammatory constituents from Zanthoxylum integrifoliolum. Jih-Jung Chen et al J. Nat. Prod. 70, 1444-8, (2007)

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Anti-inflammatory benzenoids from Antrodia camphorata. Jih-Jung Chen et al J. Nat. Prod. 70, 989-92, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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Characterization of the drug binding specificity of rat liver fatty acid binding protein. Sara Chuang et al J. Med. Chem. 51, 3755-64, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors. Morshed Alam Chowdhury et al Bioorg. Med. Chem. Lett. 18, 4195-8, (2008)

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A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9',2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-inflammatory agents. H N Hafez et al Bioorg. Med. Chem. Lett. 18, 4538-43, (2008)

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Probing lipid- and drug-binding domains with fluorescent dyes. Shannon L Black et al Bioorg. Med. Chem. 16, 1162-73, (2008)

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Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening. Mojca Brunskole et al Bioorg. Med. Chem. 16, 5881-9, (2008)

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Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. 16, 9694-8, (2008)

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2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. P X Franklin et al Eur. J. Med. Chem. 43, 129-34, (2008)

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Synthesis and anti-inflammatory evaluation of methylene bridged benzofuranyl imidazo[2,1-b][1,3,4]thiadiazoles. V B Jadhav et al Eur. J. Med. Chem. 43, 1721-9, (2008)

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NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARgamma). Nelilma C Romeiro et al Eur. J. Med. Chem. 43, 1918-25, (2008)

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Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid. Mohd Amir et al Eur. J. Med. Chem. 43, 2056-66, (2008)

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Synthesis, pharmacological activity and hydrolytic behavior of ethylenediamine and benzathine conjugates of ibuprofen. Nithar R Chatterjee et al Eur. J. Med. Chem. 43, 2819-23, (2008)

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Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens. Jean Duplex Wansi et al J. Nat. Prod. 71, 1942-5, (2008)

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Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. Nassima Abdelouahab et al J. Nat. Prod. 71, 746-9, (2008)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Morshed A Chowdhury et al J. Med. Chem. 52, 1525-9, (2009)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. Lett. 19, 3014-8, (2009)

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Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Morshed Alam Chowdhury et al Bioorg. Med. Chem. Lett. 19, 584-8, (2009)

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Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Morshed A Chowdhury et al Bioorg. Med. Chem. Lett. 19, 6855-61, (2009)

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Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies. Ahmed Z Abdel-Azeem et al Bioorg. Med. Chem. 17, 3665-70, (2009)

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Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. 17, 5182-8, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Guide to Receptors and Channels (GRAC), 4th Edition. Br. J. Pharmacol. 158 Suppl 1, S1-254, (2009)

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Synthesis of amidine and amide derivatives and their evaluation for anti-inflammatory and analgesic activities. S. M. Sondhi, et al., Eur. J. Med. Chem. 44, 1010-1015, (2009)

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Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors. Palwinder Singh et al Eur. J. Med. Chem. 44, 1278-87, (2009)

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First-principle, structure-based prediction of hepatic metabolic clearance values in human. Haiyan Li et al Eur. J. Med. Chem. 44, 1600-6, (2009)

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Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-kappaB and AP-1 mediated transcription activation and as potential anti-inflammatory agents. Rajan S Giri et al Eur. J. Med. Chem. 44, 2184-9, (2009)

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Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: synthesis and their anti-inflammatory and analgesic activities. Mymoona Akhter et al Eur. J. Med. Chem. 44, 2372-8, (2009)

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Polycyclic cage structures as carrier molecules for neuroprotective non-steroidal anti-inflammatory drugs. Louis H A Prins et al Eur. J. Med. Chem. 44, 2577-82, (2009)

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Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation. M M Alam et al Eur. J. Med. Chem. 44, 2636-42, (2009)

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Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. R V Chikhale et al Eur. J. Med. Chem. 44, 3645-53, (2009)

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Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety. K V Sujith et al Eur. J. Med. Chem. 44, 3697-702, (2009)

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Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents. B Jayashankar et al Eur. J. Med. Chem. 44, 3898-902, (2009)

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S- and C-nucleosidoquinazoline as new nucleoside analogs with potential analgesic and anti-inflammatory activity. Abdel-Rahman B A El-Gazzar et al Eur. J. Med. Chem. 44, 4249-58, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Synthesis of 6-aminomethyl derivatives of benzopyran-4-one with dual biological properties: anti-inflammatory-analgesic and antimicrobial. S M Hasan et al Eur. J. Med. Chem. 44, 4896-903, (2009)

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Manthena V S Varma et al J. Med. Chem. 53, 1098-108, (2010)

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Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors. Valentina Onnis et al J. Med. Chem. 53, 2286-98, (2010)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity. Martina Hieke et al J. Med. Chem. 53, 4691-700, (2010)

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Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Morshed A Chowdhury et al Bioorg. Med. Chem. Lett. 20, 1324-9, (2010)

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Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase. Gang Yu et al Bioorg. Med. Chem. Lett. 20, 2168-73, (2010)

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Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. Sham M Sondhi et al Bioorg. Med. Chem. Lett. 20, 2306-10, (2010)

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Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. Lett. 20, 4544-9, (2010)

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Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid. Sadaf J Gilani et al Bioorg. Med. Chem. Lett. 20, 4762-5, (2010)

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Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Yun W Alelyunas et al Bioorg. Med. Chem. Lett. 20, 7312-6, (2010)

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Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Gang Yu et al Bioorg. Med. Chem. Lett. 20, 896-902, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-kappaB and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer agents. Rajan S Giri et al Bioorg. Med. Chem. 18, 2796-808, (2010)

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A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. David Buttar et al Bioorg. Med. Chem. 18, 7486-96, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis and antiproliferative properties of ibuprofen-oligo(3-hydroxybutyrate) conjugates. Barbara Zawidlak-Wegrzyńska et al Eur. J. Med. Chem. 45, 1833-42, (2010)

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Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. Mosaad S Mohamed et al Eur. J. Med. Chem. 45, 2994-3004, (2010)

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Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives. Xian-Yu Sun et al Eur. J. Med. Chem. 45, 4807-12, (2010)

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Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives. Sham M Sondhi et al Eur. J. Med. Chem. 45, 555-63, (2010)

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Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives. Sham M Sondhi et al Eur. J. Med. Chem. 45, 902-8, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies. Zhangjian Huang et al J. Med. Chem. 54, 1356-64, (2011)

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A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies. Khaled R A Abdellatif et al Bioorg. Med. Chem. Lett. 21, 3951-6, (2011)

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Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives. Lingaiah Nagarapu et al Bioorg. Med. Chem. Lett. 21, 4138-40, (2011)

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Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids. Koneni V Sashidhara et al Bioorg. Med. Chem. Lett. 21, 4480-4, (2011)

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Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors. M Abdur Rahim et al Bioorg. Med. Chem. Lett. 21, 6074-80, (2011)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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SAR studies of acidic dual ?-secretase/PPAR? modulators. Martina Hieke et al Bioorg. Med. Chem. 19, 5372-82, (2011)

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Prediction of drug intestinal absorption by new linear and non-linear QSPR. Alan Talevi et al Eur. J. Med. Chem. 46, 218-28, (2011)

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New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. Mosaad S Mohamed et al Eur. J. Med. Chem. 46, 3022-9, (2011)

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Recent progress in synthesis and bioactivity studies of indolizines. Girija S Singh et al Eur. J. Med. Chem. 46, 5237-57, (2011)

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Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. Wukun Liu et al Eur. J. Med. Chem. 46, 907-13, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs. Sarthak Jain et al J. Med. Chem. 55, 688-96, (2012)

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In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor. Han Byul Kang et al Bioorg. Med. Chem. Lett. 22, 1198-201, (2012)

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Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids. Gehan H Hegazy et al Bioorg. Med. Chem. 20, 1259-70, (2012)

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Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: Their anti-inflammatory and anti-nociceptive activities. Syed Shafi et al Eur. J. Med. Chem. 49C, 324-33, (2012)

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Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Barnett, J., et al. Biochim. Biophys. Acta 1209, 130, (1994)

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Metabolic stereoisomeric inversion of 2-arylpropionic icids. On the mechanism of ibuprofen epimerization in rats. Chen, C.S., et al. Biochim. Biophys. Acta 1033, 1-6, (1990)

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Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. Kato, M., et al. J. Pharm. Pharmacol. 53, 1679-1685, (2001)

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