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I5018 Sigma

Anti-Interleukin-1α antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-IL-1α

Description

Immunogen

recombinant human IL-1α.

General description

The antibody does not cross-react with human IL-1β, IL-2, IL-3, IL-6, TNF-α, TNF-β, or mouse GM-CSF.

Physical form

Solution, 0.2 μm filtered, in 0.5 mL phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-Interleukin-1α antibody produced in rabbit was used in immunoblotting of anti- and pro-apoptotic proteins at a dilution of 1:1000.

Biochem/physiol Actions

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signaling through IL-1 receptor type 1. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis.

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