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  • I5152 - Anti-Interferon-γ Receptor 1 (IFN-γ R1) antibody produced in goat

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I5152 Sigma

Anti-Interferon-γ Receptor 1 (IFN-γ R1) antibody produced in goat

affinity isolated antibody, lyophilized powder

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Description

Immunogen

recombinant human IFN-γ Receptor I extracellular domain expressed in NSO cells.

General description

Human Interferon-γ- Receptor I (IFN-γ RI) is a 25kD, 227 amino acid residue containing protein that belongs to type II cytokine receptor family. IFN-γ RI has a crucial role in ligand-binding and signaling. Ligand IFN-γ induces tyrosine phosphorylation in IFN-γ RI which in turn leads to the formation of a docking site on the activated receptor for Stat1 that specifically activates IFN-γ induced gene transcription. Anti-Interferon γ Receptor I (IFN-γ RI) antibody can be used in neutralization assay using a confluent culture of HeLa cells. Goat anti-Interferon γ Receptor I (IFN-γ RI) antibody reacts specifically with recombinant human IFN-γ RI. The product has shown no cross-reactivity for recombinant human IFN-γ RII.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Application

Anti-Interferon γ Receptor I (IFN-γ RI) antibody can be used in indirect ELISA and western blot.

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