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I5879 Sigma

3-Isobutyl-1-methylxanthine

≥99% (HPLC), powder

Synonym: 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX

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Properties

Related Categories Bioactives/Supplements, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology,
InChI Key   APIXJSLKIYYUKG-UHFFFAOYSA-N
assay   ≥99% (HPLC)
form   powder
color   white to off-white
mp   200-201 °C(lit.)
solubility   DMSO: soluble1 M (with gentle warming)
  ethanol: soluble10 mg/mL
storage temp.   −20°C
Gene Information   human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Adora1(29290), Adora2a(25369)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1, 5 g in poly bottle

250 mg in poly tube

100 mg in poly bottle

Biochem/physiol Actions

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
ZD8500000
Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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