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  • I5902 - Monoclonal Anti-Interleukin-2 Soluble Receptor γ antibody produced in mouse

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I5902 Sigma

Monoclonal Anti-Interleukin-2 Soluble Receptor γ antibody produced in mouse

clone 38024.11, purified immunoglobulin, lyophilized powder

Synonym: Anti-IL-2 sRγ

Description

Immunogen

mouse cells transfected with human IL-2 soluble receptor γ.

General description

Interleukin-2 Receptor γ is a 64kD protein, that form complex with its β chain for IL-2 internalization and cell activation. It expresses in many cell types including neutrophils, thymocytes, CD4+ and CD8+ T cells, B cells, NK cells and monocytes. Mutation in IL2RG can leads to X-linked severe combined immunodeficiency (SCID) . Monoclonal anti-Interleukin-2 Soluble Receptor γ antibody can be used to block biological activity facilitated by IL-2. It can also be used for neutralizing the biological activity of IL-2 R γ. Mouse anti-Interleukin-2 Soluble Receptor γ antibody reacts specifically with human IL-2 soluble receptor γ. The product has shown no cross-reactivity with recombinant human IL-2 R α, IL-2 R β, IL-1 RI, IL-1 RII, IL-4 R, IL-6 R, IL-7 R and IL-10 R.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Application

Monoclonal anti-Interleukin-2 Soluble Receptor γ antibody can be used in immunoblotting and ELISA for detecting IL-2 R γ.

Analysis Note

The antibody will neutralize human cell surface IL-2 Rγ mediated-bioactivity.

Price and Availability


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