|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I, Ion Channels,|
|recombinant||expressed in E. coli|
Exhibits the same activity as the natural form of the toxin
The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.
5, 10, 100 μg in glass bottle
Soluble in aqueous buffers. Stock solutions of 1 μM can be aliquoted and stored at -20 °C for up to 3 months.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P260-P264-P280-P284-P301 + P310-P302 + P350|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||26/27/28|
|Safety Statements (Europe)||28-36/37-45|
|RIDADR||UN 3462 6.1 / PGII|
Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
Keywords: Absorption, Cancer, Cell proliferation, Cell signaling, Diabetes, Diseases, Hormones, Ligands, Neurotransmitters, Phosphorylations, Sequencing
Purification and characterization of a unique potent peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. Galvez, A. J. Biol. Chem. 265, 11083, (1990)
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