Iberiotoxin, recombinant from Mesobuthus tamulus
≥98% (HPLC), recombinant, expressed in E. coli
DOWNLOAD MSDS (PDF)Synonym: IbTX
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Empirical Formula (Hill Notation) C179H276N50O56S7
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Molecular Weight 4248.86
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PubChem Substance ID 24896080
Properties
| Related Categories | Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, I, Ion Channels, |
| recombinant | expressed in E. coli |
| assay | ≥98% (HPLC) |
| storage temp. | −20°C |
Description
Amino Acid Sequence
Glp-Phe-Thr-Asp-Val-Asp-C
Biochem/physiol Actions
Exhibits the same activity as the natural form of the toxin
The single chain peptide iberiotoxin (IbTX) is a selective and reversible inhibitor of high-conductance calcium-activated potassium channels (PK,Ca). It occurs naturally in the venom of the scorpion Buthus tamulus. IbTX also modulates the binding of charybdotoxin (CbTX) to smooth muscle sarcolemmal membranes in a non-competitive manner. IbTX is similar in size to CbTX and shares considerable sequence homology with CbTX. However, IbTX differs in its overall charge in having one fewer basic and four more acidic residues than CbTX.
Preparation Note
Soluble in aqueous buffers. Stock solutions of 1 μM can be aliquoted and stored at -20 °C for up to 3 months.
Price and Availability
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≥90% (HPLC)
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