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I6160 Sigma

ITK (352-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: EMT, LYK, MG C126257, MGC126258, PSCTK2

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   49-67 nmol/min·mg
mol wt   mol wt ~53 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... ITK(3702)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

ITK (IL2-inducible T-cell kinase) is important for T-cell activation through the T-cell antigen receptor. Absence of ITK in T cells causes impairment in TCR (T cell receptor)-mediated actin polymerization, cell polarization and signaling events associated with cytoskeletal reorganization.

General description

ITK (IL2-inducible T-cell kinase) is a member of the Tec family of tyrosine kinases. ITK is expressed in T-cells.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


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Biomedical Applications
Safety & Documentation
Protocols & Articles
Peer-Reviewed Papers
15

References

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