• USA Home
  • I6256 - 2-Iminothiolane hydrochloride

EMAIL THIS PAGE TO A FRIEND
I6256 Sigma

2-Iminothiolane hydrochloride

≥98% (TLC), powder

Synonym: 2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Traut’s reagent

Purchase

Properties

Related Categories Molecular Biology, Protein Modification, Protein Structural Analysis, Proteomics, Reagents for lysine modification,
InChI Key   ATGUDZODTABURZ-UHFFFAOYSA-N
assay   ≥98% (TLC)
form   powder
impurities   ≤5% Free sulfhydryl groups
mp   198-201 °C(lit.)
solubility   H2O: soluble100 mg/mL
storage temp.   2-8°C

Description

Other Notes

Note that the amidine linkage preserves original primary amine positive charge. Incorporates a five atom linker.

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

Application

2-Iminothiolane hydrochloride has been used in the synthesis of thiolated PEG (poly(ethylene glycol). It may be used to synthesize PLA-SH (polyethylene glycol-thiol) and PLA-PEG-SH (polyethylene glycol–polylactic acid-thiol).

Thiolating reagent for primary amines. Reacts at pH 7-10 by amidine bond to present free sulfhydryl. Useful in preparation of disulfide and/or thioether linked conjugates.

General description

2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.

Price and Availability


Amplified Detection
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Tailoring Collagen-Based Matrices for Regenerative Medicine and Tissue Engineering

Jiayu Leong,1 Liam Grover,2 Hyunjoon Kong1* 1Department of Chemical and Biomolecular Engineering University of Illinois, Urbana-Champaign, IL 61801 USA 2University of Birmingham, UK *Email: hjkong06@...
Keywords: Adhesion, Adsorption, Aminations, Bacterial conjugations, Biomaterials, Building blocks, Cell culture, Clinical, Deaminations, Degradations, Deposition, Diffusion, Growth factors, Hydroxylations, Immobilization, Ligands, Methylations, Michael reaction, PAGE, Purification, Recombination, Reductive aminations, Transfection

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?