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I6634 Sigma

Insulin from bovine pancreas

powder, BioReagent, suitable for cell culture

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Core Bioreagents, Cytokines, Growth Factors and Hormones,
product line   BioReagent
form   powder
potency   ≥27 USP units per mg
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   cow ... INS(280829)

Description

Frequently Asked Questions

Live Chat and Frequently Asked Questions are available for this Product.

Application

Insulin is used as a growth factor in many mammalian cell culture systems.

Biochem/physiol Actions

Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Reconstitution

Insulin has low solubility at neutral pH. It can be solubilized at 2 mg/ml in dilute acetic or hydrochloric acid, pH 2-3.

Physical form

powder-0 °C; solution stable 2-8 °C, 1 year

Price and Availability

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dry powder, for research or for further manufacturing use

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Insulin from bovine pancreas

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γ-irradiated, BioXtra, suitable for cell culture, potency: ≥25 units/mg (USP units), lyophilized powder

recombinant, expressed in yeast (proprietary host)

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Safety & Documentation

Safety Information

WGK Germany 
3

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Hyperoxia causes maturation-dependent cell death in the developing white matter. Gerstner, B., et al. J. Mol. Endocrinol. 28, 1236-45, (2008)

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A Novel Purification Method For CNS Projection Neurons Leads To The Identification Of Brain Vascular Cells As A Source Of Trophic Support For Corticospinal Motor Neurons. Dugas, J.C., et al. J. Neurosci. 28, 8294-305, (2008)

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Peroxisome proliferator-activated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents. Kadegowda, A.K., et al. J. Dairy Sci. 92, 4276-89, (2009)

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Down-Regulation of Hepatic HNF4{alpha} Gene Expression during Hyperinsulinemia via SREBPs Xie, X., et al. Mol. Endocrinol. 23, 434-43, (2009)

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Implantation increases tensile strength and collagen content of self-assembled tendon constructs Calve, S., et al. J. Appl. Physiol. 108, 875, (2010)

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Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Goff, LA Exp. Hematol. 36(10), 1354-1369, (2008)

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Species variation in the amino acid sequence of insulin. Smith, L.F. Am. J. Med. 40, 662-666, (1966)

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Insulin-sensitive glucose transport. Kono, T. Vitam. Horm. 7, 103-154, (1988)

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Zebrafish primordial germ cell cultures derived from vasa::RFP transgenic embryos. Lianchun Fan et al Stem Cells Dev. 17, 585-97, (2008)

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Long-chain fatty acid effects on peroxisome proliferator-activated receptor-{alpha}-regulated genes in Madin-Darby bovine kidney cells: Optimization of culture conditions using palmitate Thering, B.J., et al. J. Dairy Sci. 92, 2027-37, (2009)

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Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth. Ahmad S Mol. Ther. 17(6), 1101-8, (2009)

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Identification of a second lipopolysaccharide in Porphyromonas gingivalis W50. Rangarajan M J. Bacteriol. 190(8), 2920-32, (2008)

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The effect of insulin on circulating PCSK9 in postmenopausal obese women. Awan Z, Dubuc G, Faraj M, et al. Clin. Biochem. 47(12), 1033-9, (2014)

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Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus. Ian S. Zagon et al Arch. Ophthal. 127, 1468-73, (2010)

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Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy. Jodhbir S. Mehta et al Mol. Vis. 14, 1277-81, (2008)

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Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells. Naito A Cancer Sci. 99(8), 1584-8, (2008)

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Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Angel Gu et al Exp. Cell Res. 315, 1668-82, (2009)

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LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis. Huili Li et al Mol. Cancer 10, 100, (2011)

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Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells. Kang, L Oncol. Rep. 21(1), 185-92, (2009)

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Merck 14,4980

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