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  • I6904 - Anti-Inositol Hexakisphosphate Kinase antibody produced in rabbit

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I6904 Sigma

Anti-Inositol Hexakisphosphate Kinase antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IP6 Kinase

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   rabbit, mouse, human, rat
application(s)   western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 50 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... IHPK1(9807), IHPK2(51447), IHPK3(117283)
mouse ... Ihpk1(27399), Ihpk2(76500), Ihpk3(271424)
rat ... Ihpk1(50560), Ihpk2(59268)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 216-233 of human IP6 kinase.

General description

The gene IP6K1 (inositol hexakisphosphate kinase 1), also referred to as IHPK1, is mapped to human chromosome 3p21.31. The 1323bp open reading frame contains six exons that encode a protein of 441 amino acids. It is found to be expressed in several tissues, such as testis, brain, heart, pancreas, liver, kidney, and skeletal muscle.

Physical form

100 μg of affinity isolated IgG in PBS with 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.

Biochem/physiol Actions

The gene IP6K1 (inositol hexakisphosphate kinase 1) encodes a member of the inositol hexakisphosphate kinases (InsP6K) that also comprise of InsP6K2, and InsP6K3. The members of this family are involved in the conversion of InsP6 (phytic acid) to InsP7 (diphosphoinositol-pentakisphosphate), which functions in vesicular trafficking and exocytosis, apoptosis, and insulin disposition. Knock-out of this gene in mice has been shown to increase insulin sensitivity due to a decrease in the levels of InsP7, a physiologic inhibitor of Akt, a serine/threonine protein kinase that regulates glucose homeostasis. IP6K1 is found to negatively regulate PtdIns(3,4,5)P3 signaling, which in turn, regulates the function of neutrophils in innate immunity.

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