• USA Home
  • I7034 - Monoclonal Anti-Interleukin-4 antibody produced in mouse

EMAIL THIS PAGE TO A FRIEND
I7034 Sigma

Monoclonal Anti-Interleukin-4 antibody produced in mouse

clone 3007, purified immunoglobulin, lyophilized powder

Synonym: Anti-IL-4

Purchase

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   human
application(s)   immunohistochemistry: 5-15.0 μg/mL
  neutralization: suitable
  western blot: 1-2 μg/mL
clone   3007, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG1
storage temp.   −20°C
Gene Information   human ... IL4(3565)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

purified, E. coli-derived recombinant human interleukin-4.

General description

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 specifically recognizes human interleukin-4 (12-20 kDa). It does not react with mouse IL-4.

Physical form

Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.

Application

Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For immunohistochemistry, a working concentration of 15 μg/ml may be used for human tissues and 5-15 μg/ml may be used for human cells. The antibody is suitable for neutralization reactions.

Price and Availability


Antibody Explorer

Explore with Confidence

All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

I7776 Anti-Interleukin-4 antibody produced in goat, affinity isolated antibody, lyophilized powder
I8784 Anti-Interleukin-4 antibody produced in goat, IgG fraction of antiserum, lyophilized powder
I7159 Monoclonal Anti-Interleukin-4 antibody produced in mouse, clone 3010, purified immunoglobulin, lyophilized powder
I7526 Anti-Interleukin-4 antibody produced in goat, affinity isolated antibody, lyophilized powder

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?