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  • I7151 - Anti-Insulin-Like Growth Factor-I Receptor antibody produced in goat

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I7151 Sigma

Anti-Insulin-Like Growth Factor-I Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IGF-I R

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   indirect ELISA: suitable
  neutralization: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... IGF1R(3480)
biological source   goat
conjugate   unconjugated

Description

Immunogen

Recombinant human IGF-I soluble receptor expressed in Sf 21.

General description

Insulin-Like Growth Factor-I Receptor (IGF-I receptor) is a disulfide-linked heterotetrameric transmembrane protein that belongs to Tyr protein kinase family and is expressed mainly in all cells and tissues. Association of two α (130 kD) and two β (95 kD) subunits of IGF-I receptor is essential for receptor autophosphorylation. It has a pivotal role in cell growth control as well as can induce differentiation, and eventually cell death, of certain types of cells. Anti-Insulin-Like Growth Factor-I Receptor antibody can be used to block cell surface IGF-I sR mediated IGF-I and IGF-II bioactivity. Goat anti-Insulin-Like Growth Factor-I Receptor antibody reacts specifically with recombinant human IGF-I. The product has shown no cross-reactivity for other cytokines tested.

Physical form

Lyophilized from 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.

Specificity

The antibody blocks cell surface IGF-I R mediated IGF-I and IGF-II biological activity. At optimal antibody concentration, no more than 40-60% of the IGF-I or IGF-II activity can be blocked by this antibody.

Application

Anti-Insulin-Like Growth Factor-I Receptor antibody can be used in indirect ELISA and western blotting.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  3
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