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  • I7284 - Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

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I7284 Sigma

Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-CD127, Anti-Il7r

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   mouse
application(s)   flow cytometry: 3.0-10.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Il7r(16197)
biological source   goat
conjugate   unconjugated

Description

Immunogen

purified, NSO cell-derived recombinant mouse interleukin-7 soluble receptor α.

General description

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R α (CD127) chain and a γ chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signaling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signaling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally, the effect of IL-7 on cell cycle is due to the modulation of proteins p27kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4. Anti-interleukin-7 receptor α/CD127 recognizes mouse IL-7 Rα. This antibody shows less than 1% cross reactivity with rhIL-7 Rα.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Application

Anti-interleukin-7 receptor α/CD127 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry, the recommended concentration is 3-10 μg/ml/6 cells.

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Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
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I2907 Monoclonal Anti-Interleukin-7 Receptor α antibody produced in mouse, clone 40131, purified immunoglobulin, lyophilized powder
I8409 Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat, affinity isolated antibody, lyophilized powder

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