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  • I7654 - Anti-Inositol 1,4,5-Triphosphate Receptor (Type II) antibody produced in rabbit

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I7654 Sigma

Anti-Inositol 1,4,5-Triphosphate Receptor (Type II) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IP3R-II

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   rat
application(s)   immunohistochemistry: suitable
  immunoprecipitation: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 240 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   rat ... Itpr2(81678)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic petide with a sequence derived from the cytoplasmic, amino-terminus of rat IP3R-II.

General description

The gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) encodes type 2 intracellular receptor that binds to Inositol 1,4,5 trisphosphate. The gene encodes a 2701 amino acid protein that contains six membrane-spanning regions near the C-termini. The cytoplasmic N-terminal domain is involved in ligand-binding. The gene is mapped to human chromosome 12p11.

Physical form

Solution in PBS with 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.

Biochem/physiol Actions

The receptor encoded by the gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) is a Ca2+ release channel in the endoplasmic reticulum that is stimulated upon binding to its ligand inositol 1,4,5-triphosphate. It mediates intracellular calcium signaling. It facilitates the release of Ca2+ from endoplasmic reticulum and modulates intracellular Ca2+ concentration. Loss of ITPR2 gene function is found to be associated with anhidrosis and can inhibit sweat production in humans and mice.

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