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I7776 Sigma

Anti-Interleukin-4 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IL-4

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   mouse
application(s)   neutralization: suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Il4(16189)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant mouse IL-4.

General description

The antibody will neutralize the biological activity of recombinant mouse IL-4, but not recombinant human IL-4. It shows <5% cross-reactivity with recombinant rat IL-4, and shows no cross-reactivity with recombinant human IL-4.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline..

Biochem/physiol Actions

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signaling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages.

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