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  • I7892 - Anti-Interferon-γ Inducible Protein antibody produced in goat

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I7892 Sigma

Anti-Interferon-γ Inducible Protein antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-IP-10

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... CXCL10(3627)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human IP-10.

General description

Interferon-γ Inducible Protein (IP-10), also known as CXCL-10, is a cytokine that belongs to the CXC chemokine family. It is secreted in response to interferon-γ by neutrophils, monocytes, basophils, epithelial cells and keratinocytes. IP-10 is involved in chemotaxis, apoptosis, angiostasis and inhibits cell growth. The effects of IP-10 are mediated by its receptor, CXCR3. The major signalling pathways that are activated by IP-10 are those of MAPK, PKA, JNK, NF-κB and PI3K/Akt. Alteration of IP-10 levels has been observed in various infectious diseases caused bacteria, fungi and viruses such as dengue, Ebola and hepatitis B
Anti-Interferon-γ Inducible Protein antibody detects human IP-10.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose

Preparation Note

Purified using protein G.

Application

Anti-Interferon-γ Inducible Protein antibody may be used for immunoblotting at a working antibody concentration of 1-2 μg/ml. For ELISA, antibody concentration of 0.5-1.0 μg/ml is recommended.

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