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  • I8153 - Anti-Interleukin-1 Receptor Accessory Protein antibody produced in rabbit

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I8153 Sigma

Anti-Interleukin-1 Receptor Accessory Protein antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-IL-1RAcP

Description

Immunogen

synthetic peptide corresponding to amino acids 525-540 of human Interleukin-1 Receptor Accessory Protein (Il-1RAcP). This sequence is identical in mouse and rat.

General description

Interleukin-1 is a proinflammatory cytokine produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that exert their cellular effects by signaling through IL-1 receptor type 1 (IL-1R1). IL-1 recruits Interleukin-1 Receptor Accessory Protein (IL-1RAcP) that stabilizes the ligand-receptor association. IL-1RAcP is expressed by astrocytes and neurons in the brain. IL-1RAcP does not regulate the responses of IL-1 directly but modulates the gene expression and inflammatory responses induced by IL-1. IL-1RAcP is critical in mediating the activation of IRAK and SAPK pathways by IL-1. Anti-Interleukin-1 Receptor Accessory Protein antibody recognizes human, mouse and rat IL-1RAcP (~66 kDa). There is no cross-reactivity to other members in the IL-1 and IL-18 receptor families.

Physical form

Solution in phosphate buffered saline, containing 0.02% sodium azide.

Application

Anti-Interleukin-1 Receptor Accessory Protein antibody is suitable for immunoblotting at a working concentration of 0.5 μg/ml using HeLa cell extract.

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