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  • I8159 - Monoclonal Anti-Interleukin-1α/Interleukin-1F1 antibody produced in rat

I8159 Sigma

Monoclonal Anti-Interleukin-1α/Interleukin-1F1 antibody produced in rat

clone 40508, purified immunoglobulin, lyophilized powder

Synonym: Anti-Il1a



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   mouse
application(s)   capture ELISA: 2 μg/mL
  neutralization: suitable
clone   40508, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Il1a(16175)
biological source   rat
conjugate   unconjugated



purified, E. coli-derived recombinant mouse interleukin-1α/interleukin-1F1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Biochem/physiol Actions

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signaling through IL-1 receptor type 1. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis.

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Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

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