• USA Home
  • I8159 - Monoclonal Anti-Interleukin-1α/Interleukin-1F1 antibody produced in rat

EMAIL THIS PAGE TO A FRIEND
I8159 Sigma

Monoclonal Anti-Interleukin-1α/Interleukin-1F1 antibody produced in rat

clone 40508, purified immunoglobulin, lyophilized powder

Synonym: Anti-Il1a

Purchase

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   mouse
application(s)   capture ELISA: 2 μg/mL
  neutralization: suitable
clone   40508, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Il1a(16175)
biological source   rat
conjugate   unconjugated

Description

Immunogen

purified, E. coli-derived recombinant mouse interleukin-1α/interleukin-1F1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Biochem/physiol Actions

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signaling through IL-1 receptor type 1. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis.

Price and Availability


Antibody Explorer

Explore with Confidence

All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?