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I8273 Sigma

Anti-Interleukin-2 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-IL-2

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Description

Immunogen

recombinant human interleukin-2 expressed in Escherichia coli.

General description

Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4+ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle
Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It also neutralizes recombinant, mouse IL-2, but requires 30-50 times the antibody concentration required to neutralize human IL-2.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing carbohydrates.

Specificity

The antibody neutralizes the biological activity of recombinant human IL-2.

Preparation Note

Purified using protein G.

Application

Anti-interleukin-2 antibody is suitable for IL-2 neutralization assays.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  3
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Peer-Reviewed Papers
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References

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