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I8280 Sigma

Indomethacin

meets USP testing specifications

Synonym: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Biochemicals and Reagents, Core Bioreagents,
InChI Key   CGIGDMFJXJATDK-UHFFFAOYSA-N
assay   98.0-101.0%
form   powder
suitability   meets USP testing specifications
Mode of action   enzyme | inhibits
Gene Information   human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

Description

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

Packaging

5, 25, 100 g in glass bottle

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
NL3500000
Protocols & Articles
Peer-Reviewed Papers
15

References

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