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  • I8409 - Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

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I8409 Sigma

Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-CD127, Anti-CDW127, Anti-IL7R, Anti-ILRA

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   human
application(s)   flow cytometry: 5.0-10.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... IL7R(3575)
biological source   goat
conjugate   unconjugated

Description

Immunogen

purified, NSO cell-derived recombinant human interleukin-7 soluble receptor α.

General description

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R α chain and a γ chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signalling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signalling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally the effect of IL-7 on cell cycle is due to the modulation of proteins p27kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4
Anti-interleukin-7 receptor α/CD127 recognizes human interleukin-7.

Antigen Background

Interleukin-7 Receptor α/CD127 encodes a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Application

Anti-interleukin-7 receptor α/CD127 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry, the recommended concentration is 5-10 μg/ml.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
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Peer-Reviewed Papers
15

References

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I2907 Monoclonal Anti-Interleukin-7 Receptor α antibody produced in mouse, clone 40131, purified immunoglobulin, lyophilized powder
I7284 Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat, affinity isolated antibody, lyophilized powder

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