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I8529 Sigma

Insulin-like Growth Factor Binding Protein-5 human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: IGFBP-5

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
recombinant   expressed in NSO cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   calculated mol wt ~28 kDa
  mol wt 34 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   human ... IGFBP5(3488)

Description

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.

Packaging

25 μg in glass insert

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

Biochem/physiol Actions

IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.

IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.

General description

The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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