|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation, Cytokines, Growth Factors and Hormones,|
|recombinant||expressed in E. coli|
|mol wt||predicted mol wt ~7.6 kDa|
|suitability||cell culture tested|
human ... IGF1(3479)|
mouse ... Igf1(16000)
The biological activty is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line, MCF-7.
Potent mitogenic growth factor that mediates the growth-promoting activities of growth hormone postnatally. Mouse and human IGF-I share 97% sequence identity.
Insulin-like growth factor I (IGF-I) belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth.
IGF-I also known as somatomedin C, is secreted from the liver into circulation in a process regulated by pituitary growth hormone (GH) and so it mediates the growth-promoting activity of GH. In the developing embryo IGF-I is expressed primarily by mesenchymal-derived cells. After birth IGF-I expression in most extrahepatic tissues declines and hepatic expression of IGF-I becomes GH-regulated. Expression of IGF-I outside the liver is regulated differently, depending on the specific tissues. For example, gonadotropins and sex steroids regulate IGF-I expression within the reproductive system, while parathyroid hormone and sex steroids regulate IGF-I expression in bone. IGF-I is produced in several human tumors. IGF-I is mitogenic for a variety of cells including fibroblasts, osteoblasts, smooth muscle cells, fetal brain cells, neuroglial cells, and erythroid progenitor cells. IGF-I exerts its actions exclusively through the IGF-I receptor (IGF-IR). IGF-I induces endothelial cell migration and is involved in the regulation of angiogenesis.
50 μg in glass bottle
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Customers Also Viewed
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Chemically defined, recombinant from Saccharomyces cerevisiae, sterile-filtered, BioXtra, suitable for cell culture
>95% (HPLC), recombinant, expressed in E. coli, lyophilized powder
IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
recombinant, expressed in E. coli, Recombinant Analog, suitable for cell culture
Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction,...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 9–14
Keywords: Apoptosis, Huntington Disease, Transcription
Insulin-like growth factors (IGF-I and IGF-II) are mitogenic and anabolic peptides structurally homologous to insulin. IGF-I and -II are single polypeptide chains of approximately 7.5 kDa comprised o...
BioFiles 2009, 4.5, 12.
Keywords: Adhesion, Apoptosis, Cancer, Growth factors, Hormones, Infrared spectroscopy, Ligands, Transduction, transformation
Add to Cart
|I2656||Insulin-like Growth Factor-I (E3R) human, >95% (HPLC), recombinant, expressed in E. coli, lyophilized powder|
|I2157||Anti-Insulin-Like Growth Factor-I antibody produced in goat, affinity isolated antibody, lyophilized powder|
|I9409||Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster, clone 126002, purified immunoglobulin, lyophilized powder|
|I9909||Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in mouse, clone 56408, purified immunoglobulin, lyophilized powder|
|I1146||R3 IGF-1 human, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture|
|I9278||Insulin solution human, Chemically defined, recombinant from Saccharomyces cerevisiae, sterile-filtered, BioXtra, suitable for cell culture|
|I3769||Insulin-like Growth Factor-I human, IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture|
|I8773||Anti-Insulin-Like Growth Factor-I antibody produced in goat, affinity isolated antibody|
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?