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I9266 Sigma

Insulin Receptor from rat liver

buffered aqueous glycerol solution

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Description

Packaging

1 vial in serum bottle

Preparation Note

Purified by affinity chromatography on wheat germ agglutinin.

Unit Definition

One unit will catalyze the incorporation of 1 pmol per min of phosphate from γ-32P-ATP into poly(Glu,Tyr), 4:1, at 30 °C.

Physical form

Solution in 50% glycerol containing 50 mM HEPES, pH 7.6, 150 mM NaCl, and 0.1% Triton.

Application

Insulin receptor from rat liver has been used in insulin receptor kinase assay.

Biochem/physiol Actions

IR (insulin receptor) protein is a heterotetrameric receptor tyrosine kinase having α subunits for ligand binding and β subunits for tyrosine kinase activity. Insulin works thriought IR. IR is present in the cytoplasm and the nucleus.

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles

Articles

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism ...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 2011
Keywords: Apoptosis, Biological processes, Carboxylations, Catalog, Diabetes, Gene expression, Gluconeogenesis, Glycolysis, Hormones, Metabolism, Metabolites, Transcription, Transduction, Type

Peer-Reviewed Papers
15

References

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