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  • I9409 - Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster

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I9409 Sigma

Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster

clone 126002, purified immunoglobulin, lyophilized powder

Synonym: Anti-IGF-I

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Insulin-like Growth Factors (IGF),
species reactivity   mouse
application(s)   capture ELISA: 2-8 μg/mL
  neutralization: suitable
  western blot: 1-2 μg/mL
clone   126002, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG1
storage temp.   −20°C
Gene Information   mouse ... Igf1(16000)
biological source   hamster
conjugate   unconjugated

Description

Immunogen

purified, E. coli-derived recombinant mouse insulin-like growth factor-I.

General description

Insulin-like Growth Factor-I (also known as somatomedinC and somatomedin A) and insulin-like growth factor-II(IGF-II) belong to the family of insulin-like growthfactors, which are structurally homologous to proinsulin.Mature IGF-I and IGF-II are h

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Biochem/physiol Actions

Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effects of IGF-1R signaling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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