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I9529 Sigma

Interleukin-10/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

Synonym: IL-10:Fc (non-lytic)

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Properties

Related Categories Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines & Growth Factors, Cytokines and Growth Factors,
recombinant   expressed in CHO cells
assay   >98% (SDS-PAGE)
form   buffered aqueous solution
mol wt   mol wt 98 kDa
impurities   endotoxin, tested
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Il10(16153)

Description

Biochem/physiol Actions

Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It is secreted by monocytes and lymphocytes. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.

Other Notes

Dimeric fusion protein consisting of mouse IL-10 fused to mutant mouse IgG2a Fc.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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