Interleukin-6 from mouse recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, carrier free

Properties

Related Categories	Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines, Cytokines & Growth Factors, Cytokines Growth Factors and Hormones (Obesity), Cytokines and Growth Factors, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation, Cytokines, Growth Factors and Hormones, Cytokines, Growth Factors, Chemokines for Stem Cell Biology, Cytokines, Growth Factors, and Chemokines for Stem Cell Expansion, General Stem Cell Biology, Growth Factors and Cytokines, Hematopoietic Stem Cell Biology, Hematopoietic Stem Cell Cytokine and Growth Factors, IL-6 and Receptors, Interleukin-6, Interleukin-6 (IL-6), Interleukins (IL), Interleukins (IL) and Receptors, Obesity Research, Reagents and Supplements, Stem Cell Biology, Stem Cell Differentiation, Stem Cell Expansion More...
recombinant	expressed in E. coli
assay	≥97% (SDS-PAGE)
form	lyophilized powder
potency	0.02-0.2 ng/mL EC₅₀
mol wt	mol wt ~21.7 kDa
impurities	endotoxin, tested
suitability	suitable for cell culture
storage temp.	−20°C

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Description

Analysis Note

The biological activity of recombinant mouse IL-6 was measured in a cell proliferation assay using T1165.85.2.1 cells.

Biochem/physiol Actions

Interleukin-6 is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β₂), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Physical form

Lyophilized from a sterile filtered solution with no additives.

Price and Availability

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Related Papers

Interleukin-13 Induced Mucous Metaplasia Increases Susceptibility Of Human Airway Epithelium To Rhinovirus Infection Marrah, E., et al. Am. J. Respir. Cell. Mol. Biol., (2010)

Documents

Certificate of Analysis

Certificate of Origin

I9646 - Datasheet (89KB)

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages...
Jennifer Fries
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Keywords: Anti-inflammatory agents, Antitumor agents, Cancer, Cell proliferation, Gene expression, Growth factors, Transcription

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Obesity is a well-established risk factor for the development of insulin resistance. Obesity is associated with the increased deposition of lipids in non-adipose tissue with subsequent decreases in i...
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