|Related Categories||Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines,|
|recombinant||expressed in E. coli|
|potency||0.02-0.2 ng/mL EC50|
|mol wt||mol wt ~21.7 kDa|
|suitability||suitable for cell culture|
The biological activity of recombinant mouse IL-6 was measured in a cell proliferation assay using T1184.108.40.206 cells.
Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.
Lyophilized from a sterile filtered solution with no additives.
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Certificate of Analysis
Certificate of Origin
|Personal Protective Equipment||Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)|
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